Rutin 500mg, Solgar, 50’s

Rutin 500mg helps to prevent the breakdown of vitamin C.

Rutin 500mg Ingredients: Rutin, bulking agents: (microcrystalline cellulose, dicalcium phosphate, hydroxypropyl cellulose), anti-caking agents: (vegetable stearic acid. Silicon dioxide, vegetable magnesium stearate), cellulose gum, glazing agents: (hydroxypropylmethyl cellulose, vegetable glycerin (from palm kernel oil and coconut oil)).

Study:

This is a study that show that rutin could promote pancreatic cancer cells’ apoptosis (self destruction). From that study: “1) Background: pancreatic cancer is one of the most serious cancers due to its rapid and inevitable fatality, which is very difficult to treat, compared with many other common cancers. Thus, developing an effective therapeutic strategy, especially searching for potential drugs, is the focus of current research. The exact mechanism of rutin in pancreatic cancer remains unknown. (2) Method: three pancreatic cancer cell lines were used to study the anti-pancreatic cancer effect of rutin. The potent anti-proliferative, anti-migration and pro-apoptotic properties of rutin were uncovered by cell viability, a wound-healing migration assay, and a cell apoptosis assay. We used high-throughput sequencing technology to detect the change of miRNAs expression.

Immunoblotting analysis was used to detect the expression of apoptotic proteins. (3) Results: CCK-8 and EDU assays revealed that rutin significantly inhibited pancreatic cancer cells’ proliferation (p < 0.05). A wound-healing assay showed that rutin significantly suppressed pancreatic cancer cells’ migration (p < 0.05). A flow cytometric assay showed that rutin could promote pancreatic cancer cells’ apoptosis. Intriguingly, rutin significantly upregulated miR-877-3p expression to repress the transcription of Bcl-2 and to induce pancreatic cancer cell apoptosis. Accordingly, rutin and miR-877-3p mimics could promote apoptotic protein expression. (4) Conclusions: our findings indicate that rutin plays an important role in anti-pancreatic cancer effects through a rutin-miR-877-3p-Bcl-2 axis and suggests a potential therapeutic strategy for pancreatic cancer.”