Highly Absorbable DIM, Nutri Advanced, 60s

Highly Absorbable DIM Ingredients: Diindolylmethane (DIM), stabiliser: microcrystalline cellulose, capsule: cellulose. Stabilisers: vitamin E and phosphatidylcholine (soy); anti-caking agents: silicon dioxide and magnesium stearate.

Study: 

If you would like to read an article on the properties of indole-3-carbinol, this is for you. This is from the study: “Studies increasingly indicate that dietary indole-3-carbinol (I3C) prevents the development of estrogen-enhanced cancers including breast, endometrial and cervical cancers. Epidemiological, laboratory, animal and translational studies support the efficacy of I3C. Whereas estrogen increases the growth and survival of tumors, I3C causes growth arrest and increased apoptosis and ameliorates the effects of estrogen. Our long-range goal is to best use I3C together with other nutrients to achieve maximum benefits for cancer prevention. This study examines the possibility that induction of growth arrest in response to DNA damage (GADD) in genes by diindolylmethane (DIM). Which is the acid-catalyzed condensation product of I3C, promotes metabolically stressed cancer cells to undergo apoptosis.

We evaluated whether genistein, which is the major isoflavonoid in soy, would alter the ability of I3C/DIM to cause apoptosis. Plus decrease expression driven by the estrogen receptor (ER)-alpha. We evaluated expression of GADD by real-time reverse transcription-polymerase chain reaction. Proliferation and apoptosis were measured by a mitochondrial function assay and by fluorescence-activated cell sorting analysis. The luciferase reporter assay was used to specifically evaluate expression driven by ER-alpha. The estrogen-sensitive MCF-7 breast cancer cell line was used for these studies. We show a synergistic effect of I3C and genistein for induction of GADD expression. This increasing apoptosis, and for decrease of expression driven by ER-alpha. Because of the synergistic effect of I3C and genistein, the potential exists for prophylactic or therapeutic efficacy of lower concentrations of each phytochemical when used in combination.”